Alteration of hydrogen sulfide/cystathionine-?-synthase system in rats with recurrent febrile seizures
- VernacularTitle:反复热性惊厥前后硫化氢/胱硫醚-?-合成酶体系表达的改变
- Author:
Ying HAN
;
Jiong QIN
;
Xingzhi CHANG
;
Zhixian YANG
;
Junbao DU
- Publication Type:Journal Article
- Keywords:
Seizure, febrile;
Hippocampus;
Cystathionine beta-synthase;
Hydrogen sulfide
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the alteration of hydrogen sulfide (H_2S)/ cystathionine-?-synthase (CBS) system during recurrent febrile seizures (FS) in the hippocampus of developing rats. Methods: The rats were randomly divided into control group (n=8) and hyperthermia-treated group (n=22). Which was subdivided into FS group (n=8) and H group(no seizure occurred, n=9) according to whether seizures occurred. The plasma level of H_2S was detected by the spectrophotometer. The expression levels of CBS gene and protein were examined by in situ hybridization and immunohistochemistry respectively. Results: The plasma levels of H_2S were increased significantly in FS group compared with those of control group or H group. The expression levels of CBS gene and protein were enhanced in FS group compared with those of control group or H group. Conclusion: The expression levels of H_2S/ CBS system were up-regulated during recurrent FS.
