Expression and clinical significance of endothelin-1 and endothelin type A receptor gene in esophageal cancer
- VernacularTitle:ET-1及其受体ETAR在食管癌中的表达及意义
- Author:
Wenjie JIAO
;
Tianyou WANG
;
Fang DING
;
Jianping KONG
;
Zhihua LIU
;
Hao PAN
- Publication Type:Journal Article
- Keywords:
esophageal neoplasm;
endothelin-1;
reverse transcription-polymerase chain reaction
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the ET-1 and the oncogenesis, development of human esophageal cancer. Methods RT-PCR and Western blotting were employed to detect the expression of ET-1 and ETAR in the tissues of esophageal cancer and normal esophageal mucous membrane from 76 esophageal cancer patients admitted by our hospital from March to December in 2002. Results There was positive ET-1 mRNA expression in 82.7% (62/75) of the specimens of esophageal cancer and in 60% (45/75) of normal tissue and the ET-1 mRNA expression had a relation with histological grade, lymph node metastasis and clinical staging of esophageal cancer (P
