Expression of RECK gene in prostate cancer cell lines and its relationship with matrix metalloproteinase
- VernacularTitle:前列腺癌细胞株中RECK基因的表达及其与MMP的关系
- Author:
Zhenyu XU
- Publication Type:Journal Article
- Keywords:
prostate carcinoma;
RECK;
gene expression;
matrix metalloproteinases
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of RECK gene in the progression and invasion of prostate carcinoma by evaluating the expression of RECK,MMP-2 and MMP-9 genes in prostate cancer cell strains: BPH-1,DU-145,LNCap and PC-3.Methods: The mRNA levels of RECK,MMP-2 and MMP-9 were measured by RT-PCR and the protein level of RECK by Western blot analysis in the above 4 prostate cell lines.Results: The mRNA levels of RECK in DU-145,LNCap and PC-3 cells were obviously lower than those in the benign prostate hyperplasia cell strain BPH-1(P
