Role of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in lymphatic metastasis of gastric carcinoma
- VernacularTitle:VEGF-C及其受体VEGFR-3在胃癌淋巴转移中的作用
- Author:
Jinqiang YANG
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
vascular endothelial growth factor C;
lymphangiogenesis;
lymphatic metastasis
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study expressions of vascular endothelial growth factor-C(VEGF-C) and vascular endothelial growth factor receptor-3(VEGFR-3) in gastric cancer tissues and the relationship between lymphangiogenesis and lymph node metastasis of gastric carcinoma,in an attempt to study the role of VEGF-C and VEGFR-3 in lymphatic metastasis.Methods:The expressions of VEGF-C and VEGFR-3 mRNA in 67 gastric carcinoma tissue specimens and their corresponding normal gastric tissues were determined by RT-PCR.Lymphatic vessels were stained by enzyme histochemical method and the lymph node metastasis of gastric carcinoma was analyzed according to pathological records.Results:The positive rates of VEGF-C and VEGFR-3 mRNA in carcinoma tissues were significantly higher than those in normal gastric tissues(62.69% vs 34.3% and 58.21% vs 31.3%,respectively,both P
