Inhibitory effects of pravastatin on oxidative stress in kidney of diabetic rats
- VernacularTitle:普伐他汀对糖尿病大鼠肾脏氧化应激的抑制作用
- Author:
Xiaoping YANG
- Publication Type:Journal Article
- Keywords:
diabetes;
kidney;
pravastatin;
oxidative stress
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of pravastatin on oxidative stress and renal function in the kidney of diabetic rats.Methods: SD rats were randomly divided into normal control group(CN),diabetic control group(DM),pravastatin treatment group(DM+P) and melatonin treatment group(DM+M).Pravastatin or melatonin was given to streptozocin-induced diabetic rat for 8 weeks,then the general state and renal function of rats were evaluated.The serum and renal intrinsic anti-oxidant enzyme(AOE) activities and lipid peroxide levels were also examined.Results: Diabetic rat model was successfully induced.Compared with DM control group,the urinary protein excretion was lower in DM+M group((P
