Transforming growth factor-beta signal pathway and diabetic nephropathy
- VernacularTitle:转化生长因子-?信号通路与糖尿病肾病
- Author:
Yun MA
- Publication Type:Journal Article
- Keywords:
diabetic nephropathies;
transforming growth factor beta;
Smad protein
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-beta(TGF-?)signal pathway plays a critical role in the pathogenesis of diabetic nephropathy(DN)through inducing cell hypertrophy of glomerulus and renal tubule,accelerating the accumulation of extracellular matrix(ECM),and promoting glomerulosclerosis and tubulointerstitial fibrosis,etc.Smad was a newly discovered protein regulating the intracellular signal pathway of TGF-? super family.This article reviewed the studies on TGF-? signal pathway and its activating factors,roles and relevant treatments targeting the pathway in DN patients,hoping to provide references for the therapy and research of DN.
