Migration of neuronal precursors after focal cerebral ischemia in adult rats
- VernacularTitle:成年大鼠局灶性脑梗死后神经元前体细胞的迁移研究
- Author:
Xinjie TAN
- Publication Type:Journal Article
- Keywords:
neuronal precursors;
middle cerebral artery occlusion;
reperfusion;
migration
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the migration of neuronal precursors around the infarct area after focal cerebral ischemia.Methods Animal models of middle cerebral artery occlusion(MCAO) were established in 16 adult rats,and four of another 8 rats served as normal control and four underwent sham operation.Immunohistochemistry and cell count were applied to explore and contrast the migration of neuronal precursors for up to three weeks after a 2-hour episode of focal cerebral ischemia.Results The migration of neuronal precursors toward the infarct area could be found at various timepoints.The number of neuronal precursors started to increase in 1 d after reperfusion around the infarct area and reached the peak in 7 d,then declined till day 21.However,the neuronal precursors could not be examined in the corresponding non-ischemia area.Conclusion The neuronal precursors could migrate into the ischemic penumbra.It indicates that after cerebral ischemia,neuronal precursors are directed toward the sites of brain injury,where they might be in a position to participate in brain repair and functional recovery.
