Effect and modulation of ICAM-1 and VCAM-1 in the inflammatory mechanisms following cerebral ischemia
- VernacularTitle:ICAM-1、VCAM-1在脑缺血损伤炎症机制中的作用及调控
- Author:
Lihui ZHANG
;
Erqing WEI
- Publication Type:Journal Article
- Keywords:
brain ischemia;
intercellular adhesion molecules-1;
vascular cell adhesion molecule-1
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Intercellular adhesion molecules 1(ICAM-1) and vascular cell adhesion molecule 1(VCAM-1) play important roles in the inflammatory process of cerebral ischemic injury.The expression of ICAM-1 and VCAM-1 increases following cerebral ischemia;ICAM-1 and VCAM-1 promote ischemic inflammation through mediating leukocytes adhesion to the endothelial cells and eventually migration into brain tissue;the inhibition of the overexpression and effect of ICAM-1 and VCAM-1 can reduce cerebral ischemic injury.
