Researches on drug metabolism enzyme NAT2
- VernacularTitle:药物代谢酶N-乙酰基转移酶2的研究进展
- Author:
Weiwei LENG
;
Xiaomei CAO
;
Jinheng LI
- Publication Type:Journal Article
- Keywords:
NAT2;
genetic polymorphism;
drug metabolism;
bioavailability;
bioequivalence
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
NAT2 is an important drug metabolizing enzymes in humans.Polymorphisms in NAT2 gene produce variants at amino acid including seven mutation sites.In vivo NAT2 takes part in 20 kinds of drugs metabolism and activation of carcinogen.Polymorphism of NAT2 has been related to some diseases.This paper reviews the polymorphisms and genotyping about NAT2 and their implications in drug and clinical research.
