Platelet-derived nitric oxide and cardiovscular diseases
- VernacularTitle:血小板源性一氧化氮与心血管疾病
- Author:
Sujie JIA
;
Changping HU
;
Hanwu DENG
;
Yuanjian LI
- Publication Type:Journal Article
- Keywords:
pharmacology;
platelet-derived nitric oxide;
cardiovascular diseases
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Nitric oxide is an important signalling and effector molecule which plays an indispensable role in modulating the function of platelets.Recent research revealed that a L-arginine/nitric oxide pathway presented in human platelets and nitric oxide derived from this pathway was called platelet-derived nitric oxide.The impaired synthesis and release of platelet-derived nitric oxide is closely related to the onset and development of some cardiovascular diseases,such as hypertension,atherosclerosis and diabetes.Recent progress in the relationship between platelet-derived nitric oxide and some cardiovascular diseases is reviewed in this article.Thorough research in PDNO not only has great clinical significance but also contributes to finding new ideas and new target for drug therapy.
