Effect of ecdysterone on glucose consumption of HepG2 Cells
- VernacularTitle:蜕皮甾酮对HepG2细胞葡萄糖消耗的影响
- Author:
Qiu CHEN
;
Yongpeng XIA
;
Zongyin QIU
- Publication Type:Journal Article
- Keywords:
ecdysterone;
HepG2 cells;
glucose consumption;
?TC3 cells;
insulin secretion
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate whether ecdysterone is able to exert glucose-lowering effect on hepatocytes or stimulate the secretion of insulin.Methods For glucose consumption studies,the amounts of glucose disappeared from the culture medium of HepG2 cells within 24 h were determined.?TC3 cells were also used to monitor insulin secretion.Results The glucose concentrations decreased significantly by ecdysterone 1?10~(-6)～10~(-4) mol?L~(-1),while glucose consumption increased by 44%～77% with ecdysterone.Glucose consumption declined as its concentrations increased.Insulin had no effect on glucose-lowering of ecdysterone.?TC3 cells were not stimulated by ecdysterone.Conclusion Ecdysterone is able to exert glucose-lowering effect on hepatocytes which is insulin independent,but has no effect on insulin secretion.
