Effect of atorvastatin on NF-?B/I?B signal pathway and inflammation factor expression in rabbit atherosclerosis
- VernacularTitle:阿托伐他汀对兔动脉粥样硬化中NF-?B/I?B和炎症因子表达的影响
- Author:
Linlin DU
;
Zhaohui WANG
- Publication Type:Journal Article
- Keywords:
atorvastatin;
nuclear factor kappa B;
atherosclerosis
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of atorvastatin on NF-?B/I?B signal pathway,P selectin and ICAM-1 expression in cholesterol-rich diet-induced rabbit atherosclerosis.Methods 24 New Zealand white rabbits were randomly divided into three groups: control group,high-cholesterol group and atorvastatin group.Nucleus NF-?B p65 and cytoplasma I?B? were detected with Western blot technique.Plasma P selectin was detected with Immunoradioassay.Immunohistochemistry was employed to detect the expression of ICAM-1.Results Compared with the control group,the expression of nucleus NF-?B p65,P selectin and ICAM-1 increased significantly and cytoplasma I?B? reduced in high-cholesterol group(P
