Efficasy of interferon Alfa-1b combined with lamivndine in the treatment of chronic hepatitis B
- VernacularTitle:干扰素?-1b联合拉米夫定治疗慢性乙型肝炎
- Author:
Dongmei WANG
;
Ruixue CHU
;
Xinjiang WANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Interferon Alfa-1b;
Lamivudine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of interferon Alfa-lb( IFN?-lb) combined with lamivudine in the treatment of chronic hepatitis B. Methods 103 patients with chronic hepatitis B were divided into three groups which were comparable.30 patients were treated with IFN?-lb for about 6 months;38 patients were treated with lamivudine for about 12 months; And the last 36 patients were treated with IFN?-lb and lamivudine. The serum ALT,HBV-DNA,HBV-Marks were studied using electrochemiluminescence technique,fluorescent quantitation poly-merase chain reaction(PCR) and so on. Results The serum level of ALT,HBV-DNA and HbsAg in patients which were treated with IFN?-lb and lamivudjne showed significantly lower than the other groups(P
