Biological actions of human urotensin II on cardiovascular system
- VernacularTitle:人UrotensinⅡ在心血管系统中的生物学效应
- Author:
Bo DING
;
Shan GAO
;
Zhiwu CHEN
- Publication Type:Journal Article
- Keywords:
human urotensinII;
cardiovascular system;
UT receptor;
biological actions
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Urotensin II (U-II), a cyclic peptide has been initially identified as a neuropeptide of teleost fish. Subsequently, U-II has been characterized in the brain of the European green frog and has also been cloned from the human genome. Human U-II (human U-II, hU-II), composed of 11 amino acid residues is rich in cardiovascular and nervous system. As an endogenous ligand for UT receptor, hU-II exerts a broad spectrum of biological actions, such as vasoconstriction and vasorelaxation, facilitating proliferation of cardiac cells, regulating the cardiac function and playing an important role in pathogenesis of some cardiovascular diseases such as coronary heart disease and cardiac failure. The effects of hU-II on cardiovascular system were briefly reviewed as follows.
