Alterations of maternal hepatic drug-metabolizing and antioxidative enzymes in tobacco-induced intrauterine growth retardation in rats
- VernacularTitle:吸烟所致宫内发育迟缓孕鼠肝脏药物代谢酶及抗氧化酶活性的变化
- Author:
Ting WANG
;
Hui WANG
;
Hongbin TANG
;
Youe YAN
;
Hangao ZENG
- Publication Type:Journal Article
- Keywords:
tobacco;
intrauterine growth retardation;
maternal liver;
drug-metabolizing enzymes;
antioxidative enzymes
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the alterations of maternal hepatic drug-metabolizing enzymes and antioxidative function in tobacco-induced intrauterine growth retardation (IUGR). METHODS:Pregnant rats were assigned to control group and tobacco group. IUGR model was produced by smoking from gestational days (GD) 9 to GD 20. Fetuses were removed by laparotomy on GD 21. The fetal development parameters such as fetal body weights, litter size and placental weights were recorded. Subcelluar fractions of liver were prepared by differential centrifugation. Activities of drug-metabolizing and antioxidative enzymes were monitored. RESULTS:In the tobacco exposure group, fetal body weights, litter size and placental weights were significantly reduced (P
