Studies on anti-early hepatic fibrosis of no donating-oleanlic acid derivatives in rats
- VernacularTitle:一氧化氮供体型齐墩果酸衍生物ZCⅡ_2对早期实验性肝纤维化的保护作用
- Author:
Xiuying CHEN
;
Hui JI
;
Yihua ZHANG
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
NO;
oleanlic acid;
hepatic fibrosis;
NO donator;
NCX-1000PPAGESS Nitric oxide-induced PC12 cells apoptosis and protective effect of paeoniflorin$$$$ SUN Rong 1,2, WU Dong-dong1, LIU Guo-qing1 [HJ*2/5]1 Department of Pharmacology, China Pharma
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate protect effect of the NO donating-oleanlic acid derivatives on hepatic fibrosis in rats. METHODS: The rat model with early hepatic fibrosis was induced by carbon tetrachloride (CCl_4). ZCⅡ_2 at the dose of 128 and 64 mg?kg -1 had been given orally for 30 days. Serum level of the total protein (TP), albumin (ALB), the albumin/globulin (A/G) and ALT, AST. The hyaluronic acid (HA), laminin (LN), the procollagen type Ⅲ (PCⅢ) and the level of MDA, GSH-Px in liver tissues were determined. Pathological examination to reveal the extent of liver damages was observed. [WTHZ]RESULTS: ZCⅡ_2 at the dose of 128 mg?kg -1 increased the serum TP, ALB, and A/G and decreased HA, LN, PCⅢ, ALT, and AST more significantly than the model group, and hepatic pathological injury was abated to some degree. CONCLUSIONS: ZCⅡ_2 at the dose of 128 mg?kg -1 can attenuate liver damages, protect against lipoperoxidation and attenuate hepatic fibrosis induced by CCl_4.
