Effect of calcium channel blocker on the contractility and autorhythmicity of isolated instable detrusor strip in rats
- VernacularTitle:钙通道阻滞剂对大鼠离体不稳定逼尿肌收缩性和自律性的影响
- Author:
Wuhe ZHANG
;
Bo SONG
- Publication Type:Journal Article
- Keywords:
bladder;
obstruction;
detrusor;
calcium channel blocker
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of L-type and T-type calcium channel blocker on detrusor autorhythmicity, contractility in order to elucidate the pathogenesis of detrusor instability (DI). Methods Animal models of bladder outlet obstruction (BOO) were established in 33 female SD rats and another 10 served as normal control. Six weeks later, the changes of detrusor autorhythmicity and contractility were examined by means of cystometry and the in vitro detrusor strip study. Results The incidence rate of DI was 75.9%. The detrusor autorhythmicity and contractility increased evidently after BOO (P
