Polymorphisms of E-selectin gene and genetic susceptibility of ischemic stroke in Zhuang nationality of Guangxi province
- VernacularTitle:E-选择素基因多态性与广西壮族人缺血性脑卒中的遗传易感性的关系
- Author:
Yesheng WEI
;
Qunqing XU
;
Lanqing MENG
;
Feng LIANG
- Publication Type:Journal Article
- Keywords:
E-selectin;
cerebral ischemia;
gene;
polymorphism
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between polymorphisms of E-selectin gene and ischemic stroke (IS) in Zhuang nationality of Guangxi province. Methods The G98T polymorphism in the exon 2 and the S128R polymorphism in the exon 4 of E-selectin gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and DNA sequencing among 205 patients with IS of Zhuang nationality in Guangxi and 210 healthy controls. The serum level of E-selectin was determined by enzyme-linked immunosorbent assay (ELISA). Results IS group showed significantly higher serum levels of E-selectin than control group (P0.05). Conclusion E-selectin S128R polymorphism was associated with IS, and R allele may be a genetic risk factor of IS among Guangxi Zhuang natioalities, in whom the E-selectin SR genotype carriers maybe increase the risk of ischemic stroke by enhancing the E-selectin expression.
