Tocetaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer
- VernacularTitle:多烯紫杉醇联合顺铂治疗非小细胞肺癌的临床疗效分析
- Author:
Jia WANG
;
Yi LI
;
Jian YANG
- Publication Type:Journal Article
- Keywords:
tocetaxel;
cisplatin;
non-small cell lung cancer (NSCLC);
antineoplastic combined chemotherapy protocols
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and side effects of the combination of tocetaxel and cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Thirty patients were treated with the combination for two courses. Every three weeks, tocetaxel was administrated on day 1 in a dose of 75mg/m~2 and cisplatin in dose of 30mg/m~2 from day 1 to day 3. Results Complete remission was found in two patients, partial remission in fourteen patients, in seven patients there was no change, and in seven patients there was an advance of the disease. The overall remission rate was 53.3%. The main side effects were suppression of myelopoiesis, gastrointestinal disturbance, alopecia, myalgia and arthralgia. Conclusion The combination of tocetaxel and cisplatin is effective and well-tolerated in the treatment of NSCLC.
