Effects of interleukin-6 on melphalan induced apoptosis of multiple myeloma cell KM_3
- VernacularTitle:白介素-6对马法兰诱导多发性骨髓瘤细胞KM_3凋亡的影响
- Author:
Zhenzhou YANG
;
Xinghua CHEN
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
hematologic neoplasms;
interleukin-6;
melphalan;
apoptosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the robe of interleukin-6 in the apoptosis of multiple myeloma (MM) cell lines KM_3 induced by melphalan and its molecular mechanism. Methods Apoptosis was confirmed by flow cytometry, DNA fragmentation rate and TUNEL. The expression of caspase-3, caspase-8 proteins in KM_3 cell, which was assessed by Western blot analysis, after melphalan treatment and cultured with or without interleukin-6. Results KM3 cells in the presence of interleukin-6 showed lower rate of apoptosis compared with that in the absence of interleukin-6 (P
