A comparative observation of early reaction and side effects of radiotherapy IMRT and conventional radiotherapy regime for nasopharyngeal carcinoma
- VernacularTitle:鼻咽癌调强放疗和常规放疗早期反应的对照观察
- Author:
Xin LEI
;
Xiaoxia YANG
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
radiotherapy;
intensity-modulated radiotherapy
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the early effect and side effect on the radiotherapy of nasopharyngeal carcinoma patient using IMRT compared with conventional radiotherapy. Methods Seventy eight nasopharyngeal carcinoma patients were divided into IMRT group (38 patients) and conventional radiotherapy group (40 patients). After CT-sim, the radiation oncologist and physician delineated the outline of GTV, CTV, parotid gland, spinal cord and brain stem. The receiving volume of parotid, spinal cord and PTV was respectively calculated by using inversing plan. Face-neck, supracalvicular field, amte-aural field and postaural field were adopted to receive electrons during conventional radiotherapy. Seven to nine conformal fields including 80-100 sub-fields were adopted during IMRT. The reaction of skin, parotid (xerostomia) and oral mucosa were recorded during radiotherapy. Results The nasopharyngeal and para-nasopharyngeal lesions regressed completely after radiotherapy. The volume received by the parotid, spinal cord and PTV was 30%?4.8, 56%?6.7, 95%?8.6, 92%?8.1 respectively in IMRT group, and 98%?9.4, 56%?10.7, 100%?9.7, 99%?9.5 respectively in conventional radiotherapy group. The received volume of parotid in IMRT group was significantly lower than in conventional radiotherapy group. The reaction of skin was grade I in IMRT group and grade II, III in conventional radiotherapy group. The reaction of parotid (xerostomia) was grade I and II in IMRT group and grade II and III in conventional radiotherapy group. The reaction of oral mucosa was grade I to II in IMRT group and grade II and III in conventional radiotherapy group. The reactions of skin and parotid (xerostomia) were lighter in IMRT group compared with those in conventional radiotherapy group. The time of radiotherapy was 45?4.4 days in IMRT group and 51?5.3 days in conventional radiotherapy group respectively. Conclusion The radiotherapy using IMRT regime can decrease the reaction of parotid (xerostomia) and skin to complete the radiotherapy course of nasopharyngeal carcinoma patients. Moreover, it can increase the life quality in nasopharyngeal carcinoma patients after radiotherapy and also shorten the time of radiotherapy.
