Expression and distribution feature of p53, Rasp21 and C-myc oncoproteins in carcinoma of stomach
- VernacularTitle:p53、rasp21及C-myc癌基因蛋白在胃癌中的表达及分布特征
- Author:
Jie ZHOU
;
Huaren LI
;
Jinbo ZHANG
- Publication Type:Journal Article
- Keywords:
gastric cancer;
proto-oncogene protein c-myc;
protein p53;
protein p21
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of p53, rasp21 and C-myc in gastric carcinogenesis. Methods Expression and distribution feature of p53, rasp21 and C-myc in 60 cases of human gastric cancer were detected with immunohistochemical SP (Streptavidin-Peroxidase) staining. Results The positive rate of expression was respectively 51.7% for p53, 40.0% for rasp21, and 66.7% for C-myc, while in the gastric mucous membrane adjacent to carcinoma they were respectively 1.6% for p53, 13.3% for rasp21, and 15.0% for C-myc. The differences in expression of p53, rasp21 and C-myc oncoproteins in carcinoma and non-carcinoma tissues were very significant (P
