The change level of insulin and thyroxin has associate with the operation wound
- VernacularTitle:手术创伤与胰岛素、甲状腺激素的关联
- Author:
Jiwei WEI
- Publication Type:Journal Article
- Keywords:
Wounds and injuries;
Insulin;
Thyroid hormones;
Animal experimentation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of operation wound on insulin and thyroxin in serum. Methods Left hemiihepatectomy,splenectomy,orchiectomy or pseudo-operation were carried out separately on 65 healthy rabbits, which were randomly divided into experimental and control groups. The insulin and thyroxin in serum were examined by peripheral venous blood samples drawn by one day prior,24 hours, 48 hours,one week and one month after the operation respectively. Results The post-operative insulin in serum increased obviously in experimental group.One week later,it decreased gradually and reached to pre-operative level after one month of the operation.The level of TT4 and TT3 significantly decreased at 24 hour postoperatively.and gradually rose at 48 hour and up to normal levels in the first week postoperatively the raised degree of TT3 was higher than TT4, both of them approached the same level of preoperative measurement in the first month. The change insulin and thyroxin level of insulin on hemihepatectomy were higher than those on splenectomy.orchiectomy effect smaller. As a comparison,pseudo-operation had little effect on the serum insulin. Conclusions The reaction of higher insulin after operation wound is probably caused by insulin resistance. The syndrome of normal thyroid disease after opereation wound,is probably acused by stress,cytolcine,serum 5'-deiodinase or it's reduce. The change levels of insulin and thyroxin have correlation with the operation wound.
