Research progress of specific ?3 adrenoceptor agonists
- VernacularTitle:特异性?3肾上腺素能受体激动剂研究进展
- Author:
Zhaoqian LIU
;
Hong SUN
;
Yali LIU
;
Honghao ZHOU
- Publication Type:Journal Article
- Keywords:
?3 adrenoceptor;
agonist;
obesity;
diabetic mellitus;
uncoupling protein
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim ?3 adrenoceptor(?3-AR) is predominantly expressed in white and brown adipose tissue.?3 adrenoceptor agonist stimulates the lipolysis of white adipose tissue and non-shivering thermogenesis of brown adipose tissue to exert its antiobese action.Moreover,?3 adrenoceptor agonist increases the sensitivity and response of adipose tissue to insulin and it play an important role in the treatment of type 2 diabetes.In addition,?3 adrenoceptor agonist can also relax gastrointestinal spasm and show cardiovascular effect in human heart and vascular tissues.There has been increasing concerned in the study and development of ?3 AR agonists since 1983.Up to date,32 kinds of ?3 AR agonists have been identified.The development of ?3 AR agonists can provide new strategy and approach for pharmacotherapy of obesity and diabetic mellitus and will have Spaciously the used out look in the field of medicine.
