Progress in the vector-mediated drug delivery system to the brain
- VernacularTitle:促进药物跨血脑屏障转运载体的研究进展
- Author:
Biwei SONG
;
Wenxi WANG
;
Yangping NIU
- Publication Type:Journal Article
- Keywords:
blood-brain barrier;
Transferring receptor;
vector
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier(BBB) is formed by the brain capillary endothelium and excludes from the brain approximately 100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs.There are three routines to increase drug transport into brain,ie,neurosurgical,pharmaceutical chemical,and physiological ways and the later is most hopeful.The receptor-mediated transcytosis system on the brain capillary endothelium could be used as multifunctional vectors for drug active transport into brain.This provides the platform for CNS drug delivery programs.
