Protective effects of dipfluzine against the whole cerebral ischemia and reperfusion injury in rats
- VernacularTitle:双苯氟嗪对大鼠全脑缺血再灌注损伤的保护作用
- Author:
Xueyan CHEN
;
Haifang LI
;
Wei ZHANG
;
Yongli WANG
;
Yongjian ZHANG
- Publication Type:Journal Article
- Keywords:
dipfluzine;
reperfusion injury;
delayed neuronal death;
brain edema;
electric maze
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the protective effects of dipfluzine against the whole cerebral ischemia and reperfusion injury and its mechanisms.Methods Four-vessel occlusion method was used to make the cerebral ischemia-reperfusion model.In early period of reperfusion,several including LDH,MDA,SOD and brain water content were tested.And in the late period of reperfusion,the delayed neuronal death and amnesia induced by reperfusion were studied.Results The contents of brain water and MDA were increased,and the activities of SOD and LDH were decreased after ischemia and reperfusion injury.The hippocampal structure and memory of rats were also destroyed in the delayed neuronal death.Dip reversed the changes obviously.It had antagonistic effect on brain edema and lipid oxidation,it also protected the neurons of hippocampal CA1 regions from ischemia injury.Conclusion Dip had protective effects on the early stage of reperfusion injury,and delayed neuronal death after the whole cerebral ischemia and reperfusion,which were possibly due to the antagonistic effect on lipid peroxidation.
