Role of the transcription factor NF-?B in the vessel stenosis and neointima formation in balloon-injured rat artery
- VernacularTitle:转录因子NF-?B对血管成形术后血管狭窄和新生内膜形成的影响
- Author:
Jun ZHOU
;
Guoping LU
;
Wenhang QI
- Publication Type:Journal Article
- Keywords:
nuclear factor ?B;
neointima;
antisense oligonucleotide;
decoy oligonucleotide;
balloon-injury
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To examine the in vivo effect of the antisense or/and decoy oligonucleotide of NF-?B on vessel proliferation and balloon-injured monocytes chemotactic protein-1(MCP-1) and extracellular signal regulated kinase in the carotid artery of rats.Methods Sprague-Dawley rats underwent balloon-dilation injury of the left carotid artery.The rats were divided into 7 groups(n=18) and each group were further divided into 6 sub-groups for study at 6 time points(1,3,5,7,14 days,n=3).Uninjured artery of the same rat was used as the control.Results In model group,sense group and scramble group,intima/media ratio increased after 5 days and reached the maximum after 14 days;intima/media ratio in antisense group,decoy group,antisense plus decoy group decreased significantly(P
