Effects of CYP2C19 genetic polymorphism on the pharmacokinetics and pharmacodynamics of omeprazole in Chinese volunteers
- VernacularTitle:CYP2C19基因多态性对奥美拉唑在中国人体内的药物动力学和药效学的影响
- Author:
Xiangpeng HU
;
Jianming XU
;
Yongmei HU
- Publication Type:Journal Article
- Keywords:
CYP2C19;
genetic polymorphism;
omeprazole;
pharmacokinetics;
pharmacodynamics
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
4 holding time were observed among the three groups.After repeated doses,the PMs showed a significantly higher intragastric pH value than that of the homEMs or hetEMs.Conclusion The pharmacodynamic effects of omeprazole and its pharmacokinetics depend on the CYP2C19 genotype status in Chinese volunteers.
