The effect of Bay k8644 on cardiac function of myocardial ischemia-reperfusion injury in rats
- VernacularTitle:Bay k8644对心肌缺血再灌注损伤大鼠心功能的影响
- Author:
Chongming MU
;
Yupei CHEN
- Publication Type:Journal Article
- Keywords:
Bay k8644;
calcium ions;
calcium channel;
cardiac function
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of Bay k8644 on cardiac function with the model of myocardial ischemia-reperfusion injury(MIRI)in Rats.Methods Rat MIRI was induced by occluding the left anterior descending coronary artery for 40 min followed by 90 min reperfusion.Eighteen rats were divided randomly into 3 groups: saline,Bay k8644 and 0.1% dimethyl sulfoxide(DMSO)intravenously injected 30 min after ischemia.Heart functions were assessed before ischemia and 5,20 and 40 min after initiation of ischemia and 5,30,60 and 90 min after reperfusion,by measuring heart rate(HR),the left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP) and ?dp/dt_(max).Results After ischemia,LVSP and +dp/dt_(max) decreased(P
