Inhibitory effect of nicotinylsalicylic acid on rabbit platelet aggregation induced by ADP,AA and Collagen
- VernacularTitle:烟酰水杨酸对Collagen、ADP、AA诱导的兔血小板聚集的影响
- Author:
Minheng ZHU
;
Yue WU
;
Hong CHEN
;
Hui TIAN
;
Honghai LIU
- Publication Type:Journal Article
- Keywords:
nicotinylsalicylic acid;
adenosine diphosphate;
arachidonic acid;
collagen;
platelet aggregation
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of nicotinyl salicylic acid(NSA) on rabbit platelet aggregation induced by Collagen,ADP and AA.Methods Platelet aggregation induced by collagen,adenosine diphosphate(ADP) or arachidonic acid(AA) was studied with turbidimetry in rabbtis blood,in vitro and vivo.Results NSA significantly inhibited the platelet aggregation induced by Collagen and ADP,in vitro and vivo.The inhibition by NSA was dose-dependent.NSA had no effect on the platelet aggregation induced by AA.Conclusion NSA can inhibit rabbit platelet aggregation induced by Collagen and ADP.
