Roles of nitric oxide and K~+ channels in urocortin-induced relaxation on SHR thoracic aorta
- VernacularTitle:Urocortin舒张自发性高血压大鼠胸主动脉与NO和K~+通道的关系
- Author:
Hongyi WANG
;
Jie CHEN
;
Huae XU
;
Jin TAO
;
Shengnan LI
- Publication Type:Journal Article
- Keywords:
urocortin;
spontaneously hypertensive rats(SHR);
nitric oxide;
K_(ATP) channels
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the vasodilatory effect and the mechanisms of urocortin(Ucn) on the thoracic aorta of spontaneously hypertensive rats(SHR).Methods Rings cut from SHR thoracic aorta were used in vitro.The endothelium dependent and independent vasorelaxing effects of Ucn were measured.Furthermore,it was also explored whether the relaxing effects of Ucn were affected by N~((?)) nitro-L-arginine methyl ester(L-NAME), methylene blue(MB) and glybenclamide.Results Ucn(1 nmol?L~(-1)～1 ?mol?L~(-1)) caused concentration dependent relaxation in SHR thoracic aorta with endothelium and without endothelium(P
