Studies on the effects of borneol on the pharmacokinetics of carbamazepine in rabbits
- VernacularTitle:冰片对卡马西平在家兔体内药代动力学的影响
- Author:
Hongyu ZHOU
;
Ping WANG
;
Dan LIN
;
Xichong YU
;
Guoxin HU
- Publication Type:Journal Article
- Keywords:
borneol;
carbamazepine;
10,11-epoxide carbamazepine;
HPLC;
pharmacokinetics;
blood-brain barrier.
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of borneol on the pharmacokinetics of carbamazepine(CBZ) and 10,11-epoxide carbamazepine(ECBZ) in rabbits.Methods After ig administration of bornol and CBZ,the CBZ and ECBZ were determined with HPLC,then the pharmacokinetic parameters were obtained with 3P87 program on computer.Results In the CBZ-borneol combination group,the pharmacokinetic parameters of CBZ,T_(12(ka)),T_(peak) and AUC were increased,while Ka and CL were decreased.The parameters of ECBZ,T_(12(ke)) and T_(peak) were increased,while Ke was decreased.The ratio of CSF to plasma of ECBZ at the time of 0.5,1,2 hour after ig was increased.Conclusion Borneol significantly improved the bioavailability of CBZ,inhibited the metabolism of CBZ,and enhanced the ECBZ passing through blood brain barrier.
