The changes of CD4~+ cells and relevant cytokines in the blood from chronic hepatitis B patients
- VernacularTitle:CD4~+细胞及相关细胞因子在慢性乙型肝炎患者血中的变化
- Author:
Xia LIN
;
Haihong ZHU
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
CD4 positive T-lymphocytes;
Cytokines
- From:
Chinese Journal of Infectious Diseases
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of CD4~+ cell and relevant cytokines from chronic hepatitis B patients and the significance was discussed. Methods The expression of CD4,CD8 and CD28 molecules on PBMC was detected with Flow Cytometry.The levels of IL-2,IFN-?,IL-4,IL-10 and IL-12 in serum were measured with ELISA,and the liver function test including serum ALT,SB,ALP and albumin was conducted. Results Three conditions of CD4~+ ratio from PBMC in 86 patients were observed,that showed lower,similar or higher comparing with normal controls.According to CD4~+T cell ratio,the patients were divided into 3 groups.In three groups,the changes of CD28 expression paralleled to that of CD4~+T cell ratio.Except IL-4,the level of cytokines related to viral clearance such as IL-2,IFN-?,IL-10 and IL-12 in patients was elevated compared with controls(P
