Relationship between Glutathione and related enzymes and multidrug resistance
- VernacularTitle:谷胱甘肽及其相关酶系统与肿瘤多药耐药的关系
- Author:
Yi JIANG
;
Yunman LI
- Publication Type:Journal Article
- Keywords:
multidrug resistance;
glutathione;
related enzymes;
transporter;
transport mechanism;
analogs
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance to chemotherapeutic drugs is an important reason for clinical chemotherapy failure. The mechanisms of the classical drug resistance such as P-gp, MRP have been clarified. Hence, it is very important to further study the non-classical mechanism of multidrug resistance. We introduced the effects on MDR, the possible mechanisms of glutathione and related enzymes, as well as the relationship between structure of GSH analogues and the transport activity in this paper.
