Effects of rutecarpine on movement of gastrointestinal tractin experimental animals
- VernacularTitle:吴茱萸次碱对胃肠道运动影响的实验研究
- Author:
Xiaohu WANG
;
Weiwei WU
;
Baolin LIU
- Publication Type:Journal Article
- Keywords:
rutecarpine;
gastric emptying;
gastrointestinal transit;
ileum;
acetylcholine;
histamine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate effects of rutecarpine on the movements of gastrointestinal tract in experimental animals. METHODS: In mice, the accelerated movement model of intestinal transit was induced by neostigmine, and metoclopramide or apoplon was applied to induce the accelerated gastric emptying movements. Acetylcholine or histamine was used to induce the contractions occurring in the isolated ileum from guinea pigs. RESULTS: Rutecarpine inhibited normal intestinal transit and demonstrated more effective suppression on the accelerated movement induced by neostigmine in mice; meto- clopramide and apoplon induced-accelerated gastric emptying movements were also significantly inhibited by rutecarpine in a dose-dependent manner. Meanwhile rutecarpine significantly inhibited the isolated ileum contractions induced by acetylcholine or histamine. CONCLUSION: Rutecarpine is an effective inhibitor to intestinal motility and this activity is probably mediated by its antagonistic effects on the cholinergic nerve or its responsible modulations.
