Effect of BCEF0083, bioactive compounds from Entomogenous fungi, on AVP content of hypothalamus, pituitary and expression of glucocorticoid receptor mRNA of hippocampus in chronic unpredictable stress model of depression in rats
- VernacularTitle:一种白僵菌代谢产物BCEF0083对慢性应激抑郁大鼠下丘脑、垂体精氨酸加压素含量及海马GR mRNA表达的影响
- Author:
Hongwei KAN
;
Yan CHENG
;
Lanlan ZHOU
;
Liang MING
- Publication Type:Journal Article
- Keywords:
chronic stress;
entomogenous fungi;
AVP;
glucocorticoid receptor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of bioactive compounds from Entomogenous fungi (BCEF0083), on AVP content of hypothalamus, pituitary and expression of glucocorticoid receptor (GR) mRNA of hippocampus in chronic unpredictable stress model of depression in rats. METHODS: The depression animal model was induced by chronic unpredictable stress. The effect of BCEF0083 on AVP content in hypothalamus and pituitary was tested by radioimmunoassay. RT-PCR was used to test the expression of GR mRNA in hippocampus. RESULTS: BCEF0083 decreased the AVP content of hypothalamus and pituitary in chronic unpredictable stressed rats, and increased the expression of GR mRNA of hippocampus in chronic stressed rats. CONCLUSION: BCEF0083 exhibits antidepressant effect by attenuating the stimulated function of hypothalamus-pituitary-adrenal axis in chronic unpredictable stress model of depression in rats.
