Determination method of CYP3A activity and individualization dosage regimen of etoposide
- VernacularTitle:CYP3A酶活性测定方法与依托泊苷个体化给药方案
- Author:
Shunguo ZHANG
;
Jian ZHANG
;
Minling CHEN
- Publication Type:Journal Article
- Keywords:
etoposide;
leukemia;
CYP3A activity;
individualization;
dosage regimen
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the correlation between drug concentration of etoposide (VP16) and CYP3A activity (CA) in leukemia. METHODS: The urinary 6?-hydroxycortisol/hydrocortisone ratio is a useful marker for CA. Concentration of VP16 in plasma and CA was determined by HPLC in 20 leucemia patients, and the correlation analysis was performed using the SPSS software. RESULTS: Correlation analysis between drug concentration of VP16 and CA in leukemia was poor correlated (r = 0.725), but concentration of VP16 and lgCA showed a good correlated (r =0.969). CONCLUSION: It is feasible to adjust the therapeutic regimen of VP16 by determining CA.
