No Association Between the 5-HT 2A Receptor Gene Promoter Polymorphism(-1438A/G) and Schizophrenia in a Korean Population.
- Author:
Hyun CHO
1
;
Ik Seung CHEE
;
Jung Woo SON
;
Young Ho LEE
Author Information
1. Department of Psychiatry, College of Medicine, Chungnam National University, Taejon.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
5-HT 2A receptor gene promoter;
-1438A/G polymorphism
- MeSH:
Alleles;
Genotype;
Humans;
Polymerase Chain Reaction;
Schizophrenia*;
Serotonin*
- From:Journal of Korean Neuropsychiatric Association
2001;40(2):334-341
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was designed to investigate the association between 5-HT 2A receptor gene promoter -1438A/G polymorphism and schizophrenia in a Korean population. METHOD: 5-HT 2A receptor gene promoter -1438A/G polymorphism was typed with Polymerase Chain Reaction in 132 patients with schizophrenia and 138 healthy normal controls. RESULT: There was no difference in allelic frequency of -1438A/G polymorphism between patients with schizophrenia and controls(K 2=2.261, df=1, p=0.133). A difference was found in genotype distribution(K 2=6.157, df=2, p=0.046), but this difference was being given by the increased A/A in th controls and A/G in the patients. The genotype frequency, which is the sum of homozygosity and heterozygosity for the -1438 G allele, was significantly higher in the patients(K 2=5.880, df=1, p=0.015). However, there was no difference between the patients with schizophrenia and conrols in the frequency of homozygosity for the -1438 G allele. CONCLULSION: These results suggest that -1438A/G polymorphism of the 5-HT 2A receptor gene promoter is not causally related to the development of schizophrenia in a Korean population.
