STUDY OF THE COMBINED PREVENTIVE EFFECT OF FOLIC ACID AND VITAMIN B_(12) ON THE DEVELOPMENTAL TOXICITY OF ALCOHOL
- VernacularTitle:叶酸和维生素B_(12)联合抗酒精发育毒性的实验研究
- Author:
Yunan TANG
;
Yajun XU
;
Xiujuan WANG
;
Zengli YU
;
Xiaoyi SHEN
;
Yong LI
- Publication Type:Journal Article
- Keywords:
folic acid;
vitamin B12;
developmental toxicity;
alcohol
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the combined preventive effect of folic acid (FA) and vitamin B12 (VB12) on the developmental toxicity of alcohol. Methods: To build animal model with the developmental toxicity by giving 5g/kg bw alcohol (25% ethanol) intragastrically (IG) to ICR mice during gestational day (GD) 6-15. In addition to alcohol, three groups were given FA 60 mg/kg bw, VB12 1 mg/kg bw, FA 60 mg/kg bw + VB12 1 mg/kg bw respectively by IG during GD1-GD16. An alcohol model group and a negative control group were set. All dams were killed at GD18. Results: Compared to the alcohol model group, the pregnant mice of FA + VB12 combined intervention group put on more weight during pregnancy; the live fetal rate; the fetal weight, body length and tail length were all increased; the abnormal ossification rate of sternum, occipital bone, and four limbs dropped (P
