THE IMMUNOLOGIC PROTECTION OF SELENIUM ON GASTRIC MUCOSAL LESIONS OF MICE INFECTED BY HELICOBACTER PYLORI
- VernacularTitle:亚硒酸钠对幽门螺杆菌所致小鼠胃黏膜组织损伤的免疫保护作用
- Author:
Shihe SHAO
;
Jibin LIU
;
Xiujie DUAN
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
selenium;
HP;
BALB/C mice model
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the immunologic protection of selenium on gastric mucosal lesions of BALB/C mice infected by Helicobacter pylori (HP). Method:The model was built by ig HP in BALB/C mice and then effects of selenium on gastric mucosal lesions and the CD4、CD8 cells were observed.HP was examined by both of bacterial culture and rapid usease test (RUT). Results:1.0 ?g/g bw selenium could effectively prevent gastric mucosal damages induced by HP. HP could decreased the ratio of CD4 to CD8,but selenium could enhance the activity of CD4 cell and increase the ratio. Conclusion: Se can effectively prevent the gastric mucosal damages of mice infected by HP. One of the mechanisms is that Se can enhance the CD4 activity and increase CD4 /CD8.
