Effect of acute hypoxia with simulated high altitude on expression of orexins in rat hypothalamus
- VernacularTitle:模拟间断性低氧对大鼠下丘脑核团食欲肽分泌的影响
- Author:
Jian WANG
- Publication Type:Journal Article
- Keywords:
Acute hypoxia of high altitude;
Orexins;
Hypothalamus
- From:
Parenteral & Enteral Nutrition
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of acute hypoxia with simulated high altitude on the expression of orexins in rats hypothalamus. Methods: Rats were exposed to different high altitude(3 000 m,(4 000) m,5 000 m and 6 000 m for 8 h daily) in a hypobaric chamber.The expression of orexins in rat hypothalamus was determined by immunohistochemistry and the pathology changes of rat hypothalamus was observed with transelectricity. Results: The number of orexin-A immunoreactive positive cells in hypothalamus decreased obviously with hypoxia for 1 day(P
