The biological functions of intestinal epithelial tight junctions and its role in intestinal barrier
- VernacularTitle:肠上皮细胞紧密连接的生物学功能及在肠屏障中的作用
- Author:
Zhiguang GAO
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Tight junction;
Cell polarity;
Occludin;
Claudin
- From:
Parenteral & Enteral Nutrition
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Tight junctions(TJs) are the primary junctions between intestinal epithelia.TJs serve as the maintenance of epithelial cell polarity and the rate-limiting barrier to passive movement of hydrophilic solutes across intestinal epithelia.It plays an important role in maintaining integral intestinal epithelia,protecting intestinal barrier and preventing bacterial endotoxin and other toxin into body.This review is about biological functions,molecular regulating mechanisms of intestinal epithelial tight junctions and some factors affecting on them.
