Relationship among the characteristics of anemia, serum level of erythropoietin and the renal tubulointerstitial injury in drug-associated renal parenchymal acute renal failure patients
- VernacularTitle:药物相关肾实质性急性肾衰竭患者的贫血特征、红细胞生成素水平及其与肾损害的关系
- Author:
Yanjing ZHANG
;
Xiaomei LI
- Publication Type:Journal Article
- Keywords:
kidney failure,acute;
Anemia;
Erythropoietin
- From:
Journal of Peking University(Health Sciences)
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To recognize the characteristics of anemia in patients with drug-associated renal parenchymal ARF and to investigate the possible relations among Hb, serum level of EPO and the renal tubulointerstitial injury. Methods: Sixteen in-patients with drug-associated renal parenchymal ARF (including ATN and ATIN groups)for the last five years and 8 healthy volunteers (control group) were assessed in this study. The general information of these patients was analyzed retrospectively. Anemia related laboratory parameters, serum EPO, serum creatinine (Scr) and the renal tubular function from the samples on the time of renal biopsy in each group were compared. For pathological comparison of renal tubulointerstitial pathological changes, renal biopsy specimens from 5 patients with mild non-IgA mesangial proliferative glomerulonephritis were used as negative controls. The pathological changes in renal tubules and interstitial area were semi-quantitive scored by a computer imaging system. The correlations between Hb and EPO levels, as well as EPO level and renal function or pathological injury index were analyzed, respectively. Results: There was no significant difference among the ages, genders and the time intervals both from the administration to the onset of the disease and from the onset to the kidney biopsy among ATN and ATIN groups. Scr level was all higher than that in the control group (P
