Expression of survivin and its clinical significance in non-small cell lung cancer
- VernacularTitle:survivin在非小细胞肺癌中的表达
- Author:
Yingjia REN
;
Qingyu ZHANG
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Arrestin;
Carcinoma,non-small-cell lung;
Protein P53
- From:
Journal of Peking University(Health Sciences)
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of survivin in non-small cell lung cancer (NSCLC) and analyze its relationship with clinic opathological features and the expression of p53. Methods: The expression of survivin and p53 in 61 cases of NSCLC were detected by immunohistochemistry using monoclonal antibodies against human survivin protein and P53, respectively. Results: The expression of survivin in NSCLC could be detected in cytoplasm and/or in nucleus. The overall immunoreactivity was found in 77.0% (47/61) of tumors. Cytoplasmic, nuclear and both immunoreactivities were present in 26.2% (16/61), 8.2% (5/61) and 42.62%(26/61) respectively. The cytoplasmic and nuclear immunoreactivities in squamous cell carcinoma (57.6%, 19/33) were higher than that in adenocarcinoma (25%, 7/28) and there was significant difference (P
