Study on association of apolipoprotein J gene polymorphism with type 2 diabetes mellitus
- VernacularTitle:载脂蛋白J基因多态性与2型糖尿病相关性分析
- Author:
Ting ZHANG
;
Keren SHAN
;
Xiaolan QI
- Publication Type:Journal Article
- Keywords:
T2DM ApoJ Gene polymorphism Deletion/insertion
- From:
Chinese Journal of Practical Internal Medicine
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between apolipoprotein J(ApoJ)gene polymorphism and type 2 diabetes mellitus(T2DM).Methods The exons 3、4、7、8 of ApoJ gene were screened by polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)in 61 type 2 DM patients and 60 healthy control subjects of Chinese population.Abnormal bands were sequenced.Results The deletion/insertion polymorphism site in exon 7 of the ApoJ gene on two subject groups had significant difference (P0.05).Conclusion ApoJ of exon 7 deletion/insertion polymorphism is one of the genetic marker of 2 DM and the ApoJ polymorphism may be associated with 2 DM.
