Surgical left ventricular repair combined with skeletal myoblast transplantation for ischemic congestive heart failure after myocardial infarction
- VernacularTitle:左心室成形术结合骨骼肌成肌细胞移植治疗心肌梗死后心力衰竭
- Author:
Yong CUI
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
heart failure,congestive;
myoblasts,skeletal;
cell transplantation;
cordiomyoplasty
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the therapeutic effect of combined procedure of surgical left ventricular repair (LVR) and skeletal myoblast transplantation for congestive heart failure after myocardial infarction. Methods: Forty-eight male adult Lewis rats, with a four-week old myocardial infarction created by left coronary artery ligation, were randomized into 4 groups: group Ⅰ (n=10) received phosphate-buffered saline (PBS) injection into the border zone of the infarction; group Ⅱ(n=11) received myoblast injection ; group Ⅲ(n=13) received left ventricular repair and simultaneous PBS injection; and group Ⅳ (n=14) received left ventricular repair and myoblast injection. Echocardiography was performed once a week until the fourth week after the treatment. Results: Left ventricle end diastolic diameter (EDD) and end systolic diameter (ESD) declined significantly one week after the LV repair in group Ⅲ and Ⅳ, then increased as time passed; on the fourth week, there were no statistical differences between group Ⅰ,Ⅱ and Ⅲ, but group Ⅳ was still much smaller than the other 3 groups(P
