Gamma-scintigraphic evaluation of colon-targeted thymosin ?1 tablets
- VernacularTitle:胸腺肽?1结肠释放片在人体内?-闪烁扫描示踪研究
- Author:
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
thymosin?1;
colon-targeted tablets;
gamma-scintigraphy;
gastrointestinal tract transit
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the in vivo behavior of colon-targeted thymosin ?1 (T?1) tablets. Methods: Colon-targeted T?1 tablets were labelled with ~(99m)Tc and were given to 6 healthy male volunteers orally. Gamma-scintigraphy was used to monitor the gastrointestinal transit and release site of the labelled drug. Results: The labelled drug became detectable in the colon 6.5 h after administration in 5 volunteers with normal intestinal peristalsis and 4.5 h after administration in 1 with sthenic intestinal peristalsis. The images caused by drug release became notable in the colon with the prolongation of releasing time. Conclusion: T?1 tablets is colon-targeted during drug delivery in human gastrointestinal tract.
