Pathologic changes of blood-brain barrier in the early stage of severely scalded rabbit
- VernacularTitle:严重烫伤早期兔血脑屏障病理学观察
- Author:
Jun HU
- Publication Type:Journal Article
- Keywords:
burn;
blood-brain barrier;
vascular endothelial cell
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathologic changes of the opening blood-brain barrier(BBB) in the early stages of 50% TBSA scalded rabbits.Methods Ten male rabbits inflicted with 50% TBSA of Ⅲ degree were randomized into five groups: control,postburn 1 h,2 h,3 h,4 h.Brain tissues were isolated at different phases and observed in gross,by microscope and transmission electron microscope.Results Endothelial cells swelled and BBB began to open in 2 h after scald.The tight junction of endothelial cells became vague and the opening of BBB increased as lesion time prolonged.Conclusion As the lesion time prolonged,the injury of endothelial cells became more serious and the opening of BBB progressed,which resulted in the formation of brain edema.
