The expression of integrin ?_(1) and its prognostic significance in osteosarcoma
- VernacularTitle:整合素?_1在骨肉瘤中的表达及其临床意义
- Author:
Tian GAO
;
Qiaonan GUO
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
integrin ?_(1);
prognosis
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of integrin ?_(1) in human osteosarcoma_()and its relationship to prognosis.Methods The expression of integrin ?_(1)was measured by immunohistochemistry and its relationship to prognosis was analyzed statistically.Results Twenty-five of 34 osteosarcoma specimens were found positive staining of integrin ?_(1)(73.5%).The expression levels of integrin ?_(1)was not related to Dahlin classification of osteosarcoma,age and sex,but significantly increased in the osteoblast type and was related to poor survival.Conclusion Integrin ?_(1) can serve as a new biological indicator for the prognosis in osteosarcoma.
