Effects of heat stress on TNF-?-induced fever and the content of cAMP in rat hypothalamus
- VernacularTitle:热应激对大鼠TNF-?性发热及下丘脑中cAM P含量的影响
- Author:
Lidan LIU
;
Yan LI
;
Xiaolan WU
;
Yu CAO
;
Shufen ZHAO
- Publication Type:Journal Article
- Keywords:
heat stress;
HSP70;
TNF-?;
cAMP;
fever
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects of heat stress on TNF-?-induced fever and the content of cAMP in rat hypothalamus. Methods ①We examined the peak time of HSP70 expression in hypothalamus after heat stress; ②We studied the change of TNF-?-induced fever and the content of cAMP in hypothalamus after heat stress. Result The maximum expression of HSP70 in hypothalamus was attained at 12 h after heat stress. Heat stress limited TNF-?-induced fever and decreased the content of cAMP in hypothalamus. Conclusion Heat stress can inhibit TNF-?-induced fever in rats, and this effect may be related with the inhibition of cAMP synthesis induced by high expression HSP70 in hypothalamus.
